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Murray volvió a perder su saque en el primer game del segundo, pero quebró de inmediato.
El excampeón Stan Wawrinka, ganador del título en 2014, logró 32 winners para superar 6-2, 4-6, 6-2 a Jiri Vesely.
Tomas Berdych, Marin Cilic, Dominic Thiem, Pablo Carreño Busta, Alexander Zverev y Albert Ramos-Viñolas también avanzaron, ese último a costa del argentino Carlos Berlocq.
Más tarde, el español Rafael Nadal enfrenta a Kyle Edmund. Nadal ha ganado este torneo en nueve ocasiones.
